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שורה 1:
שורה 1: − + − When we give a dose of drug (DOG),+ − form 1 molecule up to any higher amount,+ − there is the Maximal Effect Dose (MED),+ − by means of treatment (changing a current state for a better one).+ − Thus, we also have dosages which are Non Maximal Effect Dosages (NMEDs).+ − The ratio between any NMED to the MED, is called the Margin Of Safety (MOS). + − There is an accepted formula to calculate MOS (to translate it to a dose).+ − MOS translated into a dosage is called a Terapheutic Index (TI).+ − To calculate TI, two different dosages are given to one group of examinees (in different, isolated periods).+ − The one which helps in at least 50% of the cases is the TI, the desired dosage.+ − More dosage.+ − More risk.+ − Due to law of mass action.+
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Dose Response Curve (DRC):
Dose Response Curve (DRC):
When we give a dose of drug (DOG),
form 1 molecule up to any higher amount,
there is the Maximal Effect Dose (MED),
by means of treatment (changing a current state for a better one).
Thus, we also have dosages which are Non Maximal Effect Dosages (NMEDs).
The ratio between any NMED to the MED, is called the Margin Of Safety (MOS).
There is an accepted formula to calculate MOS (to translate it to a dose).
MOS translated into a dosage is called a Terapheutic Index (TI).
To calculate TI, two different dosages are given to one group of examinees (in different, isolated periods).
The one which helps in at least 50% of the cases is the TI, the desired dosage.
More dosage.
More risk.
Due to law of mass action.
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